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中华肩肘外科电子杂志 ›› 2022, Vol. 10 ›› Issue (04) : 379 -383. doi: 10.3877/cma.j.issn.2095-5790.2022.04.016

综述

滑膜间充质干细胞的来源、生物学特性及在肩袖损伤修复中的应用
居家宝1, 丁镇涛1, 马明太1, 张一翀1, 陈建海1,()   
  1. 1. 100044 北京大学人民医院创伤骨科
  • 收稿日期:2021-11-09 出版日期:2022-11-05
  • 通信作者: 陈建海
  • 基金资助:
    国家自然科学基金(82102553); 北京大学人民医院研究与发展基金(RDY2021-23)

Synovial mesenchymal stem cell: origin, biological behavior and applicaton in rotator cuff repair

Jiabao Ju1, Zhentao Ding1, Mingtai Ma1   

  • Received:2021-11-09 Published:2022-11-05
引用本文:

居家宝, 丁镇涛, 马明太, 张一翀, 陈建海. 滑膜间充质干细胞的来源、生物学特性及在肩袖损伤修复中的应用[J]. 中华肩肘外科电子杂志, 2022, 10(04): 379-383.

Jiabao Ju, Zhentao Ding, Mingtai Ma. Synovial mesenchymal stem cell: origin, biological behavior and applicaton in rotator cuff repair[J]. Chinese Journal of Shoulder and Elbow(Electronic Edition), 2022, 10(04): 379-383.

1968年,Friedenstein等[1]首次发现大鼠骨髓中存在一群可以形成成纤维样细胞集落的细胞,并在体外能够分化为骨组织,移植到小鼠体内后可以重建造血微环境。1991年,Capian[2]将骨髓中具有上述特征的细胞首次命名为骨髓间充质干细胞(bone marrow mesenchymal stem cell, BMMSC)。随后,将肌肉、脂肪、胎盘、脐带等不同组织中的前体细胞统一命名为间充质干细胞(mesenchymal stem cell, MSC)。2001年,De Bari等[3]首次从人膝关节滑膜中分离出滑膜间充质干细胞(synovial membrane mesenchymal stem cell, SMMSC)。2016年,国际细胞治疗学会(international society for cellular therapy, ISCT)对MSC的特征进行了统一描述。MSC在体外培养时需符合以下特点:(1)能够黏附在培养皿中并增殖;(2)细胞表面表达CD73、CD90和CD105标记物,但不表达CD45、CD31、CD34、CD14、CD11b、CD79a、CD19和HLA-DR;(3)在合适条件下可以分化为骨细胞、软骨细胞和脂肪细胞[4]

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